Dimethyl Isotope Labeling Assisted De Novo Peptide Sequencing
نویسندگان
چکیده
منابع مشابه
De novo peptide sequencing by deep learning.
De novo peptide sequencing from tandem MS data is the key technology in proteomics for the characterization of proteins, especially for new sequences, such as mAbs. In this study, we propose a deep neural network model, DeepNovo, for de novo peptide sequencing. DeepNovo architecture combines recent advances in convolutional neural networks and recurrent neural networks to learn features of tand...
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Many software tools have been developed for the automated identification of peptides from tandem mass spectra. The accuracy and sensitivity of the identification software via database search are critical for successful proteomics experiments. A new database search tool, PEAKS DB, has been developed by incorporating the de novo sequencing results into the database search. PEAKS DB achieves signi...
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MOTIVATION Mass spectrometry (MS) instruments and experimental protocols are rapidly advancing, but de novo peptide sequencing algorithms to analyze tandem mass (MS/MS) spectra are lagging behind. Although existing de novo sequencing tools perform well on certain types of spectra [e.g. Collision Induced Dissociation (CID) spectra of tryptic peptides], their performance often deteriorates on oth...
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The analysis of the amminoacidic sequence of a peptide is a basic and fundamental issue in Proteomics. Such analysis is generally performed by using Mass Spectrometry equipment. This procedure exhibits several advantages on other methods. In particular, a mass/mass (or tandem mass) analysis is very often used. This latter technique produces a spectrum displaying the molecular weight of the full...
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ژورنال
عنوان ژورنال: Journal of the American Society for Mass Spectrometry
سال: 2010
ISSN: 1044-0305
DOI: 10.1016/j.jasms.2010.08.007